Best Fat Burner Supplements 2025: 10 Best Diet Pills for Weight Loss

Today's weight loss innovations help you burn fat and build muscle at the same time.

Fat burners often have caffeine megadoses, synthetic additives, and trendy ingredients that simply don't work well. The best fat burner supplements this year are changing all that.

Now, there is a new generation of formulas that take a smarter approach to weight loss. They produce significant weight loss results in a more comfortable, healthy and sustainable way:

• Stimulate enzymes that spark fat breakdown and mobilization
• Boost thermogenesis to burn more calories during exercise
• Protect, preserve and build muscle during exercise and fasted training
• Promote lean body metabolism that helps maintain weight loss
• Encourage the body to burn fat rather than storing fat
• Strengthen appetite control, especially in conjunction with exercise
• Deliver fat-burning stim (if you prefer it) in an innovative new form

Let's learn more about nutrients for fat loss, which may be taken solo, as pre-made stack supplement, or as a combination of several different supplements and of course healthy eating habits in general.

The list of the best fat burners includes:

• Chili Pepper Extract - Top stim-free fat burner triggers thermogenesis and promotes fat oxidation.¹
• Coleus Forskohlii - Ancient traditional herb shown in modern research to support muscle while maximizing fat loss²
• Black Pepper Extract - Natural thermogenic with metabolism-boosting properties that help to maximize nutrient absorption³
• GTF Chromium - Essential mineral in glucose-tolerance factor (GTF) form helps enhance insulin activity and food metabolism⁴
• HMB - Muscle-builder helps you perform physically on a calorie deficit and helps burn fat rather than break down muscle⁵
• MCT Oil - Alternative fuel powers you through fasted training; also works as a low-calorie satiating food oil⁶
• Protein - Foundational nutrition for muscle building and overall muscle health, bonus appetite regulating effects⁷
• Caffeine - Helps fat loss many ways; increases calorie burning, reduces calorie intake and promotes fat oxidation⁸
• Prebiotic - An ultramodern new prebiotic form is clinically shown to reduce caloric intake and support satiety⁹
• BCAA - Research has linked higher BCAA intake to weight loss via energy expenditure and glucose tolerance effects ¹⁰

Top Fat Burners in Supplements

Let's take a closer look at some of the top-ranked ingredients that are found in today's most effective fat burner supplements:

Chili Pepper Extract

Red hot chili peppers triggers the release of hormones that raise body heat, as evidenced by flushing and sweating you may experience while eating a spicy meal.

That same flushing effect reflects chili peppers' two primary fat-burning bioactivities:

1. Triggering thermogenesis, also known as raising energy expenditure (EE). In this state, you burn more calories than otherwise. Cayenne's thermogenic effects may be especially helpful for burning as many calories as possible during exercise session.¹¹
2. Stimulating fat-burning hormones, which has been suggested to help with lipolysis (the breakdown and mobilization of fat) as well as fat oxidation when taken in vicinity to exercise.¹²

Chili pepper is great for many people seeking to lose weight this year without stimulation because it mimics the fat burning benefits of caffeine via safe, natural stim-free pathways.

Chili pepper for fat burner supplements: Capsimax®

Capsimax® is chili pepper extract standardized to 2% capsaicinoids (active ingredients). Its buffered OmniBead™ microsphere technology protects capsaicinoids through the stomach and then releases them in the intestines -- eliminating the gastric burning associated with hot peppers. 

As a result, Capsimax® is the only supplement brand that supplies capsaicinoids’ weight control and metabolic support without gastric burning side effects

Coleus Forskohlii

Coleus Forskohlii is an herb that has been used for centuries in the Indian traditional Ayurvedic system.

It's the preferred source an active ingredient called forskolin that is prized in modern times, especially in fat burner supplements.

Forskolin is a leading ingredient in fat burner supplements due to its unique bioactivities that can be summed up as helping you to burn fat and manage your weight while building muscle.

This may sound too good to be true. But human research studies have suggested that the ForsLean® form of Coleus Forskohlii appears to help reduce fat while simultaneously boosting lean body mass.

• Researchers have attributed forskolin's fat loss benefits to its influence on hormones and enzymes that are involved in thermogenesis, anabolism, metabolism, lipolysis and more.¹³

Like cayenne pepper extract, Coleus Forskohlii is important this year's best fat burners because more people are looking for stim-free supplement solutions for burning fat and losing weight while boosting muscle. 

Coleus Forskolhii for fat burner supplements: ForsLean®

ForsLean® is Coleus Forskohlii standardized to 10% forskolin. It is the most advanced and research-backed form of this herb.

In fact, ForsLean® is made using patented nutrition technology that has been shown in human research to help shift body composition towards lean muscle, and away from fat.¹⁴

Black Pepper Extract

If red hot chili peppers are the most effective peppers for fat loss, black pepper might just be the fat burner runner-up.

Black pepper extract is used in fat loss supplements because it supplies an active ingredient called piperine, which has been shown in research to raise metabolism and body temperature, which in turn enhances the bioavailability of other nutrients.

In other words, piperine has been shown to help the nutrients you take in foods and supplements to efficiently reach your bloodstream so they can work better.¹⁵

In fat loss supplements specifically, bioperine also adds fat-blocking support, and may regulate the way fat is stored in the body.¹⁶

Black pepper extract is a smart ingredient choices for fat burning stack supplements because it brings its own unique fat loss bioactivities while also helping the other ingredients in the supplement to be absorbed and utilized more effectively.

Most effective black pepper for fat loss: BioPerine®

BioPerine® is black pepper extracted to 95% piperine. Regular raw black pepper is far less potent, only supplying 3-9% piperine. BioPerine® is also the only black pepper that is patented to increase absorption, bioavailability and utilization of nutrients.

BioPerine® is the top form to look for in the best fat burners because of its high quality, patented applications, and its body of research – which is greater than any other branded form of black pepper extract

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GTF Chromium

You may have heard about chromium as a mineral for fat loss. The GTF version stands for glucose tolerance factor, which is the right kind to look for in fat burner supplements.

As the name suggests, GTF chromium is suggested to regulate insulin. This bioactivity may in turn block fat storage and improve insulin sensitivity (potentially helping with insulin resistance, which is linked to overweight and obesity).

A clinical research review that examined 11 different research studies concluded that GTF chromium supplementation may be linked with significant reductions in body weight.¹⁷

Most effective chromium for fat loss supplements

NutriGenesis® GTF Chromium is a clean, cultivated mineral form complexed with cofactors for peak bioavailability and superior weight loss support. Ultramodern vitamins, minerals and aminos: Clean, absorbable and effective 

Because it is grown on cultures in a sterile lab, NutriGenesis® GTF Chromium is also the cleanest, most ethical and eco-friendly fat burner nutrients humans can consume.

HMB (ß-Hydroxy ß-Methylbutyrate)

HMB is an emerging fat loss ingredients because it helps to support today's healthiest and most effective fat loss strategy: Building muscle and burning fat for desirable lean body composition.

HMB is found in top fat burning supplements for its potential to support:

Anabolic Activities: HMB helps stimulate muscle growth factors, increases muscle proteins synthesis, while protecting existing muscle tissues from the damaging effects of enzymes that are generated during exercise.¹⁸

Athletic Performance: HMB has a buffering effect on muscles that may help to enhance endurance. It has also been suggested to support strength and optimize oxygen utilization during exercise.

Lipolysis (fat burning): HMB has been suggested to promote burning of fat for fuel (and not breaking down muscle for fuel) in the context of training on an empty stomach.¹⁹ It may be especially useful for fat loss on fasted training.

HMB may also play a role in fat storage, and has been suggested to help encourage the body to burn fat instead of packing it on as extra pounds.

Medium-chain triglycerides (MCT)

If you have done any kind of keto dieting, you have probably heard about medium-chain triglycerides (MCT).

Taken in supplement form as an oil or powder, MCTs have some important fat burner benefits for keto dieters specifically, but helps with all other fat loss regimens, as well.

In a ketogenic state, the body is running on fumes.

Without glucose from carbohydrates, you can get brain fog and experience physical weakness. Both of these factors make it hard to stay on your diet and exercise with sufficient intensity to lose fat.

• MCT oil is like a supercharged energy-efficient battery that kicks in when your body runs out of carbohydrate fuel.

It does so by quickly raising levels of ketones in the body.²⁰

As an alternative fuel, MCT can help you to maintain energy while in ketosis or doing fasted training. It helps to keep you clearheaded and strong, where otherwise you might be facing keto fog challenges.

But you don't have to be on a keto diet to benefit from MCT Oil. It supplies a range of other beneficial bioactivities that help with fat loss, including

• Helping with appetite control; helping satiety²¹
• One of the best fat burners for thermogenesis and boosting energy expenditure²²
• Serving as a lower-calorie oil that you can add to foods²³

As an oil used in foods, drinks, shakes, etc., MCT can help you to reduce caloric intake while also helping you to burn more calories. That's a win-win.

Most effective MCT for healthy fat loss: C8+10 from Organic Coconuts

There are 4 different MCTs that we find in nutritional supplements.

Caprylic (C8) and Capric (C10) are the most important when it comes to fat loss applications, and the most effective for all the other MCT benefits too like metabolism and brain health.

The other two, C6 and C10, offer lesser benefits and greater side effects. They are notorious for triggering gastric distress, which you may have heard about in the context of MCT Oil, and especially in coconut oil.

Supplementing with C8 and C10 delivers greater MCT fat loss benefits and less digestive side effects.

For the most effective MCT oil experience, look for C8 and C10 from organic, non-GMO coconuts that are distilled and purified for a clean, potent and effective final product. 

Protein

There is a strong theme across the best fat burners this year:

• The best fat loss supplements and strategies include a combination of fat burning and muscle building support.

Protein is the foundational nutritional supplement for building muscle. This is crucial to fitness regimens designed for fat loss, because protein can help to build, repair and protect muscle in so many different ways.

For dieters, protein has a satiating effect that helps keep your appetite in check.²⁵

Today's top protein supplements deliver muscle-building, appetite-satisfying protein in a clean powder format, with few calories and little or no dietary fat.

Even better, our best protein powder for fat loss also pleases your taste buds and helps with cravings to keep you on track.

Best Protein powder for weight loss: Oryzatein®

The first vegan protein powder to build muscle as effectively as whey protein, Oryzatein® is patented plant protein made from whole organic brown rice grain.

Oryzatein® is protein powder clinically shown to build muscle as effectively as whey and to supply muscle critical leucine that absorbs faster than whey leucine.²⁶

Oryzatein® is the world’s cleanest protein, made with Hexane-free extraction and low-heat technology that improves its stability and taste.

Caffeine

Caffeine is one of the best fat burners found in weight loss supplements. It has a number of beneficial activities for anyone seeking fat burning benefits.

Caffeine has been shown in clinical trials and research reviews to:

• Raise metabolic performance.²⁷ This in turn may help with fat burning and weight management
• Help with appetite control, although this particular benefit is mostly attributed to caffeine in coffee²⁸
• Enhance the fat-burning effects of exercise, potentially due to its ability to improve exercise performance and enjoyment.²⁹

Caffeine is a valuable ingredient for weight loss supplements.

Unfortunately, most fat burner supplements are using caffeine all wrong.

Typically they supply massive megadoses that may help with weight loss, but are accompanied by energy spikes and crashes, jitters, sleeplessness, irritability and other side effects. 

Today's advanced fat burner supplements take a new approach that unlocks caffeine's true weight loss-supportive potential.

Most effective for fat loss: Enhanced low-dose caffeine 

Low-dose caffeine may be the secret to getting the greatest fat-burning benefits without the side effects.

The best fat burners are going stim-free so that the user can instead add caffeine in a more careful and precise way, such as with a low-dose caffeine fat burning supplement.

Another strategy for improving caffeine is to combine it with L-Theanine, an amino acid found in green tea. L-Theanine + Caffeine is popularly used to reduce caffeine side effects, and is a great addition to fat burner stacks.

Human clinical trials also show L-Theanine + Caffeine (as 2:1 Suntheanine® L-Theanine to Natural Caffeine) produces an effect that enhances stimulation for better performance, especially cognitive performance, which you really need while shedding pounds.

Researchers have attributed this benefit to L-Theanine's ability to reduce caffeine side effects.³⁰ 

Prebiotics

Prebiotics are a type of beneficial fiber shown to possess several beneficial bioactivities for overall health and wellness, including for weight loss.

In the context of losing weight, prebiotics have been shown to help by:

1. Boosting the gut's microbiome with friendly bacteria, which helps with brain chemicals that are related to fat loss;
2. Optimizing metabolism of dietary sugars and fats;
3. Safely and naturally promoting feelings of appetite satisfaction.³¹

Including a good prebiotic supplement in your fat burning program is a safe, smart and natural way to get better results, all while enhancing gut health and more.

Very Good Prebiotic for fat loss: Orafti® Synergy1

Orafti® Synergy1 is a patented prebiotic ingredient called Inulin-FOS made from natural chicory root. It has been clinically shown to optimize the microbiome and reduce caloric intake, and therefore holds the greatest potential for fat loss applications.

Branched-Chain Amino Acids (BCAA)

BCAA is commonly known as a nutrient for athletes. But sports nutrition and exercise are closely related to healthy weight loss.

In conjunction with strength training, BCAA has been shown in human research to promote greater fat loss, an increase in lean muscle mass, and strength gains.³²

BCAA fat loss: NutriGenesis® and Ajipure®

Ajinomoto® + NutriGenesis® are the two cleanest, most bioavailable BCAAs you can take for fat loss applications.

Ajipure® BCAAs are made from non-GMO, gluten-free vegetable-derived carbohydrates using patented, eco-friendly Ferment-A-Pure technology.

NutriGenesis® is lab-grown BCAAs complexed with absorption-enhancing natural cofactors including probiotics, fiber, enzymes and antioxidants.

In combination, Ajinomoto® + NutriGenesis® form an especially powerful BCAA combination for athletic performance and fat burner stacks.

Conclusion

Fat burner supplements have needed to be updated for years. The good news is, there are now smarter, safer and more effective fat burner supplements.

Burn Lab Pro® supplies all of today's leading fat burner supplements in one clean, ultramodern product.

Burn Lab Pro® is the flagship fat burner: A stack supplement that is carefully designed to help you shed pounds safely, comfortably and without stimulation.

Not only that, all of our Performance Lab® supplements are designed to stack together seamlessly and synergistically to create the best fat burner stacks available right now. 

And you can stack Performance Lab® supplements with Burn Lab Pro®

For example, Performance Lab® Caffeine+ can be added in 1-capsule increments to Burn Lab Pro®. Each capsule will add 50 mg of performance-enhanced caffeine, so you can scale up until you determine your ideal dosage for weight loss and fat burner applications. 

You can take all of the Performance Lab® fat burner supplements in this guide, or just one or two. As many or as few as you take, you can be certain that each supplement is clean, premium and designed to perform.