6 Best Immune System Booster Supplements 2025

The best immune system booster supplements this year must meet today's complex immune system needs.

Now, immune challenges seem to just keep on coming. Plus, some modern factors weaken our immune function, such as low intake of vitamins and minerals, aging, intense exercise, stress and toxins.

This article discusses how today's top picks help meet these modern demands, and in doing so, strengthen your natural defenses. They are:

1. LC-Plasma (IMMUSE™) - Special probiotic activates 5 classes of immune cells; broad-spectrum help that's perfect for this year
2. Glutathione (Setria®) - Antioxidant helps Natural Killer (NK) immune cells, gut barrier & maintains defenses during exercise
3. Vitamin D (NutriGenesis®) - Sunshine vitamin: important for both short- and long-range immune responses, but many people fall short
4. Vitamin C (NutriGenesis®) - Popular immune nutrient; versatile defender helps immune cells, antioxidant status, barriers & more
5. Zinc (NutriGenesis®) - Low Zinc intake appears to suppress defenses; healthy levels optimize immune cells & improve antioxidant status
6. Selenium (NutriGenesis®) - Antioxidant mineral required for robust defenses; boosts glutathione & immune T-Cells & NK Cells

This guide explains why this list of supplements is great for this year. We conclude with a supplement that combines them all, followed by more stacking strategies to max-out your support.

Smartest strategy for boosting your defenses this year: Broad-spectrum immune system support

There are a lot of immune system booster supplements on the market today. But there are even more challenges.

That's why for this year, the best immune support strategy may involve getting broad-spectrum nutrition.

Today's best formulas deliver critical essential nutrients that you may be missing, as well as delivering new breakthroughs for truly next-level immune performance.

With the right supplements, you can support healthy immune defenses from many angles, including:

• Innate responses: Fast-acting first responses to challenges
• Adaptive responses: Longer-range immunity that remembers challenges so you can fight them more effectively in the future
• Barrier functions: A crucial aspect of robust immune performance, including barrier functions keep pathogens out of the bloodstream
• Immune cell activation and coordination: Call immune cell "troops" to action and help them communicate to fight off invaders

Let's now take a closer look at the 6 supplements that provide broad-spectrum nourishment for today's complex challenges.

Top 6 Immune System Booster Supplements

1. LC-Plasma

LC-Plasma is a heat-exposed probiotic (Lactococcus lactis), similar to lactic acid probiotics found in a famous immune-supportive food: yogurt.

LC-plasma is an important supplement discovery because it optimizes immune performance in never-before-seen ways. 

Here's how it works: typical probiotics only activate ONE class of immune cell (NK Cells).They are narrow in scope and limited in effectiveness.

LC-plasma is different: instead of activating one cell, it activates pDC (plasmacytoid dendritic cells): The Commanders of the immune system.¹

By stimulating pDC, LC-Plasma (in the advanced IMMUSE™ form) can activate 4 different types of immune cells at the same time, including:² 

1. Natural Killer (NK) Cells
2. Killer T-Cells
3. B-Cells
4. Helper T-Cells

Due to its far-reaching effects, LC-Plasma is highly efficient at promoting both innate (short-range) and adaptive (long-range) immune responses.

• pDC promotes more dynamic immune responses to more effectively fight a wider variety of immune challenges.

This discovery is years in the making. Hundreds of different probiotics have been studied, LC-Plasma is the only one shown to activate PDC.

Human research on LC-Plasma suggests significant benefits for your defenses, showing that LC-Plasma dietary supplements may help in many ways, including:

• Maintaining immune function against seasonal challenges³  
• Promoting overall wellness for work productivity and performance⁴ 
• Fighting immune challenges and fatigue associated with high-intensity training (exercise can suppress immunity)⁵ 

LC-Plasma and our next supplement, Glutathione, are effective at boosting defenses through the rigors of heavy training.

Together, LC-Plasma + Glutathione can form a powerful stack for anybody's immune health, especially athletes. 

2. Glutathione

Glutathione is one of the greatest immune system booster supplements you can take this year because of its versatile, broad-range support.

Researchers have also reported that Glutathione is essential for both innate (short-range) and adaptive (long-range) defenses.⁶ 

Glutathione is regarded for its potential to:⁷ 

1. Optimize function of T-Cell lymphocytes (white blood cells) and increase their numbers
2. Stimulate natural killer (NK) cells, helping to ramp up their production and maximize their defensive activities

Glutathione benefits for immune cells are just the beginning. It is also a versatile and powerful antioxidant, suggested by researchers to:⁸ 

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• Function as a potent antioxidant overall for human health
• Regenerate other antioxidants, including Vitamin C

Finally, Glutathione has been shown to help maintain the integrity of the gut lining: a key immune barrier for keeping pathogens at bay.

3. Vitamin D

For immune-related vitamins in particular, Vitamin D is getting a lot of headlines since COVID-19 (Coronavirus) broke out. 

Vitamin D plays a crucial role in modulating the production, differentiation and performance of various immune cells. It also has antimicrobial activity.9  

As a result, failure to get enough vitamin D has been associated with several immune issues and symptoms in research, including:10  

• Greater vulnerability to immune challenges
• Reduced numbers of lymphocyte cells
• More difficulty fighting off infections

Many people are not getting enough vitamin D. This shortfall may be worse in those who spend a lot of time indoors, since sunshine is required for natural production of vitamin D.

Researchers have suggested that nearly 50% of the global population fall short on Vitamin D.¹¹ 

Taking vitamin D helps maintain ideal levels and compensate for some of the modern factors that deplete vitamin D.

4. Zinc

Just like vitamin D, the mineral zinc has been generating a lot of buzz lately for its role as an important immune nutrient.

The body needs zinc in order to produce immune cells. Low zinc has been shown to impair T-cells and B-cells.¹² 

Zinc also possesses antioxidant activity that contributes to robust defenses while also protecting healthy cells.

Zinc's importance for healthy immune system function is especially apparent in those who fail to get enough of this critical mineral.

Researchers and clinical studies have suggested that low zinc levels may be linked with immune concerns and symptoms including:¹³ 

• Diminished overall immune system function (serious zinc deficiency)
• Diminished immune cell functions (mild zinc deficiency)

A worldwide survey says 17% of the population is deficient in zinc.¹⁴ 

Even more have suboptimal zinc intake. Taking care to supplement with Zinc can help ensure ideal levels for healthy defensive performance.

There are many different forms and sources of zinc on the market, but some can be difficult to take because of gastric distress and metallic taste side effects.

For a more comfortable and effective zinc experience, take a high quality, natural mineral form that includes absorption-boosting cofactors.

5. Vitamin C

Vitamin C is probably the first essential nutrient that pops into your mind when thinking about immune system supplements.

Indeed, it may be the most popular overall nutrient taken for immune health, and with good reason.

Vitamin C is an impressive immune health multi-tasker. Research and clinical studies say it plays key roles in some of the most important immune system functions, including:¹⁵  

• Helping to activate immune responses
• Stimulating production of immune cells
• Supplying immune-boosting antioxidant activity

In addition, vitamin C optimizes collagen production, which helps with immune barrier functions throughout the whole system.

Vitamin C deficiency is rare. Regardless, it is most popularly taken in supplements with higher dosages during times when a boost is desired.

6. Selenium

It may not be as well known as vitamin D, zinc, and vitamin C, but selenium is no less important for immune system function. 

First and foremost, selenium supplies special proteins called selenoproteins that are raw materials for making immune cells – specifically, natural killer cells and T cells.

Beyond its role in immune cell formation, selenium supplies good antioxidant activity with a big bonus: It helps the body to produce more glutathione.¹⁶ 

Just like with vitamin D and zinc, selenium insufficiency seems to interfere with healthy immune responses.¹⁷ 

Researchers and clinical studies suggest that up to 1 billion people in the world may be deficient in selenium.¹⁸  

Selenium supplements might just be very important for restoring the ideal levels you need to strengthen your natural defenses.

Now that we have covered the top supplement overall, let's discuss some other best supplements you can add-on to really take your natural defenses to the next level.

Conclusion on the Best Immune System Booster Supplements 

If you are looking for stronger, broader-acting dietary supplements to boost your immune system and meet today's complex health challenges, then PL-Immune is it.

Consider it the flagship Performance Lab® formula for supporting immune health. It also stacks seamlessly with the other Performance Lab® supplements in this article, for stronger help when desired.